Reza Salavati has a broad background in RNA biochemistry, molecular biology, and bioinformatics. He laid the groundwork for his research program by integrating computational and experimental approaches. His group developed methods to generate a comprehensive understanding of the mechanisms of gene regulation and protein-protein interaction network of trypanosomatid pathogens. He established a high throughput screen, identified potential inhibitors for RNA editing that kill T. brucei in vitro, and proposed the mechanism of inhibition. These are promising compounds which contribute to an exciting possibility for future drug development against these important pathogens.
1. Systems biology of trypanosomatid pathogens to identify key genes and pathways and determining their function
2. Post-transcriptional gene regulation and fundamental characterization of the RNA editing complex in trypanosomatid pathogens as a drug target
The model organisms under study are three related trypanosomatid pathogens, together known as the Tritryps: Trypanosoma brucei聽group,聽T. cruzi聽, and聽Leishmania聽species. Respectively, these parasitic pathogens cause African sleeping sickness (and related diseases in animals), Chagas鈥� disease, and the spectrum of diseases called Leishmaniasis.
Current Research
Systems analysis of trypanosomatid genomes
Dynamics and developmental regulation of the editosome function in trypanosomatids
Targeting the essential pathways in trypanosomatids for drug discovery
Courses
BTEC 650. Therapeutic Antibody Design.
Credits:3
Offered by:Parasitology (Graduate Studies)
Terms offered:Fall 2025
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Description
Principles and methodologies of structure-based molecular design, optimization, and development of therapeutic monoclonal antibodies. Role in therapy and diagnosis;
structural features of various types of antibodies; dissection of antibody-antigen interactions; in silico affinity maturation; manipulation of antigen specificity by point mutagenesis; using antibody Fc domain to modulate pharmacokinetics and
effector functions; design of antibody conjugates carrying toxic payloads; engineering T-cells with chimeric antigen receptors; evaluation and improving antibody immunogenicity and aggregation; antibody humanization.
Prerequisite: 400-level or higher level course in biochemistry and bioinformatics, or permission of instructor
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BTEC 555. Structural Bioinformatics.
Credits:3
Offered by:Parasitology (Faculty of Agric Environ Sci)
Terms offered:Winter 2026
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Description
Fundamentals of protein structure and the application of tools for structure determination, how protein structure allows us to understand the complex biological functions, and how knowledge of protein structure can contribute to drug discovery.
Winter
1-hr lecture, followed by 2 hrs of computer lab.
Prerequisite: Molecular biology or biochemistry, and basic bioinformatics, or permission of instructor.
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