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DESCRIPTION:On the Use of Computational Models to Improve Understanding of 
 Cardiovascular System Dynamics\n\nMette Olufsen\, North Carolina State Uni
 versity\n	Tuesday September 23\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/
 j/87078928687\n	In Person: 550 Sherbrooke\, Room 189\n	\n	Abstract: The incor
 poration of mathematical models in data analysis is essential for understa
 nding physiological processes and developing better diagnosis and treatmen
 t strategies. The primary focus will be on the use of computational models
  for the study of cardiovascular system dynamics. Vascular function is typ
 ically assessed either from non-invasive images\, including Echocardiogram
 s\, CT scans\, or MRI\, or time series measurements of heart rate\, blood 
 flow velocity\, and blood pressure. We combine the former with fluid dynam
 ics models predicting flow in vascular networks perfusing a given organ an
 d the latter to examine how the system is regulated\, e.g.\, in response t
 o a head-up tilt test\, the Valsalva maneuver\, or active standing. Indepe
 ndent of the model type\, the use of a mathematical/computational model in
  clinical practice requires that the model be calibrated and validated aga
 inst data. Most models are defined by a system of equations\, with paramet
 ers describing how different model components are connected. Calibrating t
 he model to data involves determining parameters that identify the patient
  being studied. To do so\, we use sensitivity analysis to identify how inf
 luential each parameter is\, we use subset selection to determine what par
 ameters can be estimated given the model and available data\, and paramete
 r inference to determine unique values for the influential parameters. Usi
 ng this workflow\, we can calibrate any of the models studied to data and 
 subsequently perform in-silico simulations to examine how changes can impa
 ct observed dynamics. Example studies will explore how to distinguish symp
 athetic and parasympathetic blood pressure in patients with autonomic dysf
 unction\, the use of micro-balloons in patients with pulmonary hypertensio
 n\, and how to track patients after a heart transplant.\n
DTSTART:20250923T160000Z
DTEND:20250923T170000Z
SUMMARY:QLS Seminar Series - Mette Olufsen
URL:/science/channels/event/qls-seminar-series-mette-o
 lufsen-367813
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