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DESCRIPTION:Systems Approaches to Decipher the Molecular Mechanisms of Evol
 utionary Innovation\n\nAnne-Ruxandra Carvunis\, University of Pittsburgh\n
 	Tuesday October 17\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/868554815
 91\n	In Person: 550 Sherbrooke\, Room 189\n	\n	Abstract: The yeast genome con
 tains more than 200\,000 open reading frames (ORFs)\, of which ~5\,000 are
  annotated with confidence as protein-coding genes. Most yeast ORFs are sh
 ort and lack evidence of conservation between closely related species or b
 etween isolates. These sequence properties are consistent with the notion 
 that these ORFs transiently emerge and then disappear with random mutation
 s in the absence of selection. As a result\, these ORFs remain unannotated
 . However\, we show by integrative ribosome profiling analyses that up to 
 20\,000 unannotated yeast ORFs are translated. Through systematic analyses
  of gain- and loss-of-function mutants\, high-content microscopy and integ
 rative transcriptomics\, we are uncovering evidence that transiently emerg
 ing ORFs carry a surprisingly profound impact on cell biology and fitness 
 despite their seemingly random evolutionary patterns. We discuss the impli
 cations of our findings for the systems biology of evolutionary innovation
 .\n
DTSTART:20231017T160000Z
DTEND:20231017T170000Z
SUMMARY:QLS Seminar Series - Anne-Ruxandra Carvunis
URL:/qls/channels/event/qls-seminar-series-anne-ruxand
 ra-carvunis-350906
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