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DTSTAMP:20250629T005556Z
DESCRIPTION:Leveraging Molecular and Clinical Data to Better Understand Alz
 heimer’s Disease\n\nMarina Sirota\, University of California\, San Francis
 co\n	Tuesday April 18\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/8685548
 1591\n\nAbstract: Alzheimer's disease (AD) is a multifactorial neurodegene
 rative disorder caused by interactions among multiple genetic and environm
 ental factors. Apolipoprotein (APO) E4 has been identified as the major ge
 netic risk factor for AD. It increases the risk and lowers the age of onse
 t of AD in a gene dose–dependent manner. The genetic complexity and multif
 actorial nature of AD pose unique challenges for developing effective ther
 apies and suggest the need of a precision medicine approach that takes int
 o account individual variability. We aim to use an integrative approach le
 veraging publicly available human genomics and transcriptomics as well as 
 electronic medical record data to elucidate sex-specific and apoE genotype
 -specific molecular pathways involved in AD with a focus towards neuroinfl
 ammation. We are further interested in seeing how these differences impact
  diagnostics and therapeutics. We leverage different techniques including 
 supervised as well as unsupervised machine learning and computational drug
  repurposing in order to achieve these goals.\n
DTSTART:20230418T160000Z
DTEND:20230418T170000Z
SUMMARY:QLS Seminar Series - Marina Sirota
URL:/qls/channels/event/qls-seminar-series-marina-siro
 ta-347817
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