BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250629T165142EDT-0913koTOaX@132.216.98.100 DTSTAMP:20250629T205142Z DESCRIPTION:Mapping of trabecular bone anisotropy in 3D: a tool to decipher the loading history of bones using microCT\n\nNatalie Reznikov\, 51³Ô¹ÏÍøU niversity\n Tuesday April 25\, 12-1pm\n Zoom Link: https://mcgill.zoom.us/j/ 86855481591\n\nAbstract: Trabecular bone anisotropy\, describing preferent ial trabecular co-alignment\, is a proxy for its long-term loading history . Trabecular anisotropy varies locally\, thus rendering averaged calculati ons across an entire bone inutile. I will present a 3D trabecular anisotro py mapping method using vector fields where each vector reflects the exten t of local co-alignment of the elementary units of surface. Such 3D vector fields were constructed and rendered independently by magnitude and by di rection using micro-computed tomography of four presumably nonpathologic h uman calcanei and compared their anisotropy signature with pathologically loaded calcanei in club foot and calcaneonavicular ankylosis. In the nonpa thologic calcaneus\, a pattern of four anisotropy trajectories (bands) was consistently identified. Both pathologic specimens deviated from the nonp athologic pattern. The calcaneus in the congenitally disused club foot sho wed very low local anisotropy values and no stress trajectories. The ankyl osed calcaneus showed lower anisotropy than the nonpathologic calcaneus\, but not to the same extent as the club foot . The directionality of co-ori ented stress trajectories was barely discernable in the ankylosed calcaneu s as compared to nonpathologic calcaneus. The anisotropy signature of the nonpathologic calcaneus is consistent with a kinetic loading pattern attri butable to walking. The loss of this kinetic loading results in an absent/ vanishing anisotropy signature. Such 3D mapping adds new dimensions to qua ntitative bioimaging of bone and the understanding of skeletal adaptation. \n DTSTART:20230425T160000Z DTEND:20230425T170000Z SUMMARY:QLS Seminar Series - Natalie Reznikov URL:/qls/channels/event/qls-seminar-series-natalie-rez nikov-347488 END:VEVENT END:VCALENDAR