BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250626T183321EDT-1034bMwCiX@132.216.98.100
DTSTAMP:20250626T223321Z
DESCRIPTION:Morgan Craig (University of Montreal)\n	Tuesday November 26\, 12
 -1pm\n	McIntyre Medical Building\, Room 1034\n\n'Quantitative approaches ad
 dressing intratumour heterogeneity and its impact on therapeutic outcomes'
 \n\nAbstract: Typically\, two primary forms of intratumour heterogeneity (
 ITH) are studied\, intrinsic and acquired\, both affecting the cause and t
 he progression of disease. Indeed\, the dramatic range of genetic and phen
 otypic diversity that is conferred during tumour evolution\, comprising bo
 th passenger and driver mutations\, is an underlying driver of acquired re
 sistance that can significantly impact therapeutic responses and sensitivi
 ties to new\, more targeted agents. However\, other factors influencing IT
 H warrant investigation as they can play a major role in determining treat
 ment efficacy and overall outcomes.\n	\n	In this talk\, I will discuss how I
 TH in terms of phenotypic and proliferative heterogeneity impacts on thera
 peutic responses. The first part will focus on Cooperative Adaptation to T
 herapy (CAT) in heterogenous non-small cell lung cancer. CAT is a phenomen
 on where drug-sensitive cancer cells with different genetic and phenotypic
  features within a 3-dimensional heterogeneous tumour induce non-mutationa
 l resistance in their neighbouring cells under pressure of cancer therapy.
  Using an in silico clinical trial approach\, I will then discuss how to l
 everage cell cycle heterogeneity in late-stage melanoma to individualize a
 nd optimize combination oncolytic virus immunotherapy protocols to improve
  patient outcomes. These two recent studies highlight our work to understa
 nd pathophysiological mechanisms and patterns to rationally improve therap
 eutic strategies and provide clinically-actionable treatment designs.\n
DTSTART:20191126T170000Z
DTEND:20191126T180000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:QLS Seminar Series - Morgan Craig
URL:/qls/channels/event/qls-seminar-series-morgan-crai
 g-302455
END:VEVENT
END:VCALENDAR