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UID:20250625T221140EDT-8785gjHJJN@132.216.98.100
DTSTAMP:20250626T021140Z
DESCRIPTION:A Hybrid Mathematical Approach to Improve Chemotherapy Implant 
 Treatment of Pancreatic Cancer\n\nAdrianne Jenner (University of Sydney)\n
 	Tuesday April 16\, 12-1pm\n	Montreal Neurological Institute\, deGrandpre Co
 mmunications Centre\n	\n	Abstract: Developing an effective treatment for pan
 creatic cancer presents a unique challenge for two reasons: (1) intravenou
 s drug delivery results in limited concentration at the tumour site and (2
 ) pancreatic tumours form dense impenetrable heterogeneous masses that inh
 ibit drug diffusion. Chemotherapy-loaded implants are a promising experime
 ntal treatment that could overcome these challenges. The implants allow lo
 calised sustained delivery of chemotherapy and\, by carefully selecting th
 e implant injection site\, can bypass the dense tumour structure. Using a 
 hybrid Voronoi Cellular Automaton (VCA) and PDE modelling approach\, we op
 timize two attributes of this therapy: the drug release profile and implan
 t configuration. The implants can be made with different levels of polymer
  concentrations which affect the drug release profile. From the model\, we
  have determined the optimal release profile as a function of polymer conc
 entration. We have also quantified the dependency of treatment outcome on 
 implant location and configuration. Our model presents a unique visualisat
 ion tool for our collaborators and allows the mathematical optimisation of
  the implants to be communicated effectively. The model and techniques we 
 present could easily be translated to a range of medical applications.\n
DTSTART:20190416T160000Z
DTEND:20190416T170000Z
LOCATION:deGrandpre Communications Centre\, Montreal Neurological Institute
 \, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Seminar Series in Quantitative Life Sciences and Medicine
URL:/qls/channels/event/seminar-series-quantitative-li
 fe-sciences-and-medicine-293725
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