BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250810T112736EDT-0520KHtbO9@132.216.98.100 DTSTAMP:20250810T152736Z DESCRIPTION:What causes a neuron to spike?\n\nErik Cook\n\nPhysiology\, McG ill\n\n \n\nMost of our brain’s neurons communicate using action potential s (referred to as spikes). When a neuron generates a spike\, what does tha t spike tell us about the synaptic inputs the neuron received in its dendr ites? The answer to this fundamental question is not as straightforward as it might seem despite many years of pioneering work. In this seminar I wi ll present new experimental and modeling work on cortical pyramidal neuron s that reveals they have two dendrite-to-soma transfer functions: a slow i ntegrating sub-threshold transfer function and a much faster spike-generat ing transfer function. These two transfer function arise from the nonlinea r properties of dendrites that are much faster than the integrative proper ties of the soma. Thus\, neurons seem to preferentially extract fast dendr itic inputs\, that in turn\, generate somatic spikes.\n DTSTART:20180419T160000Z DTEND:20180419T170000Z LOCATION:1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 promenade Sir William Osler SUMMARY:QLS/CAMBAM Seminar - Dr. Erik Cook URL:/qls/channels/event/qlscambam-seminar-dr-erik-cook -286944 END:VEVENT END:VCALENDAR