BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250810T160802EDT-979401uc7n@132.216.98.100 DTSTAMP:20250810T200802Z DESCRIPTION: \n\nExcitability in Cerebellar Stellate Cells: From Latency to Runup\n\nAnmar Khadra\n\n51³Ô¹ÏÍø\n\n \n\nOur recent work has sh own that inhibitory cerebellar stellate cells\, involved in motor control\ , alter their excitability over time after patch-clamping them. They do so by increasing their excitability over time (runup) and by exhibiting pecu liar biphasic latency profile (latency to first spike). This is achieved t hrough modifying the kinetics of certain ion channels expressed on the mem brane of these neurons. Using mathematical modeling techniques\, we identi fied what these ion channels are and how their kinetics are modified. In t his talk\, I will present a model of stellate cells that explains these ou tcomes and show that these neurons are type 1 oscillators possessing a SNI C bifurcation. I will also illustrate how we used dynamical systems approa ches to explain the runup phenomenon in excitability\, the biphasic profil e in latency and the transient single spiking associated with the SNIC.\n DTSTART:20180315T160000Z DTEND:20180315T170000Z LOCATION:908\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3 655 promenade Sir William Osler SUMMARY:QLS/CAMBAM Seminar - Dr. Anmar Khadra URL:/qls/channels/event/qlscambam-seminar-dr-anmar-kha dra-285760 END:VEVENT END:VCALENDAR