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DTSTAMP:20250626T170149Z
DESCRIPTION:Saddle-Node Separatrix-Loops and Neuronal Network Dynamics\n\nK
 rasimira Tsaneva-Atanasova\, University of Exeter\n	Tuesday October 29\, 12
 -1pm\n	Zoom Link: https://mcgill.zoom.us/j/89914150820\n	In Person: 550 Sher
 brooke\, Room 189\n	\n	Abstract: Normal reproductive function and fertility 
 rely on the rhythmic release of gonadotropin- releasing hormone (GnRH)\, o
 rchestrated by the hypothalamic GnRH pulse generator. The posterodorsal su
 bnucleus of the medial amygdala (MePD)\, a brain region implicated in pro-
  cessing external environmental cues including stress effects\, acts as a 
 key regulator of the GnRH pulse generator. However\, the specific neuronal
  pathways governing the dynamic\, stress-induced modulation of GnRH secret
 ion remain largely elusive. Here we employ computational modelling and ana
 lysis to investigate the effects of dynamic inputs on GnRH pulse generator
  activity.\n\nTo this end\, we develop and analyse a mathematical model re
 presenting MePD neuronal circuits comprised of GABAergic and glutamatergic
  neuronal populations\, integrating it with our GnRH pulse generator model
 . Numerical bifurcation analysis enables us to identify critical model par
 ameters and distinct neuronal network dynamic regimes. Moreover\, our anal
 ysis highlights the significance of saddle-node separatrix-loops in influe
 ncing these dynamics. To investigate further the saddle-node separatrix-lo
 ops identified in our model\, we propose unfolding a generic heteroclinic 
 loop featuring one nonhyperbolic and one hyperbolic saddle using discrete 
 (Poincaré) maps.\n
DTSTART:20241029T160000Z
DTEND:20241029T170000Z
SUMMARY:QLS Seminar Series - Krasimira Tsaneva-Atanasova
URL:/qls/channels/event/qls-seminar-series-krasimira-t
 saneva-atanasova-360220
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