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UID:20251108T092853EST-4086bB7jeX@132.216.98.100
DTSTAMP:20251108T142853Z
DESCRIPTION:\n	The prefrontal cortex (PFC) plays an important role in regula
 ting social functions in mammals\, and impairments in this region have bee
 n linked with social dysfunction in psychiatric disorders. Yet little is k
 nown of how the PFC encodes social information. I will present our work on
  the representation of social stimuli in the prefrontal cortex of mice\, a
 nd show that both the preference for social odors and the experience-depen
 dent refinement of social odor representations are impaired in a genetic m
 ouse model of autism.\n\nThe PFC is embedded in multiple brain-wide networ
 ks regulating behavior. Dissecting the contribution of such long-range syn
 aptic interactions between distant circuits requires techniques for select
 ively manipulating these connections. We have previously shown that common
 ly used inhibitory optogenetic tools are inappropriate for silencing presy
 naptic terminals\, due to the unique biophysical properties of this cellul
 ar compartment. We have now developed a new approach for silencing presyna
 ptic neurotransmitter release using a unique invertebrate rhodopsin that s
 electively couples to the Gi/o signaling pathway and acts to suppress syna
 ptic transmission in vitro and in vivo. I will describe the engineering of
  this tool and its application in behaving mice.\n\nThis seminar will be g
 iven online via Zoom.\n
DTSTART:20200529T150000Z
DTEND:20200529T160000Z
LOCATION:via Zoom\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y
 6\, 3655 promenade Sir William Osler
SUMMARY:Online Seminar - Prefrontal representation of social information an
 d a new optogenetic approach for dissecting long-range neural communicatio
 n
URL:/physiology/channels/event/online-seminar-prefront
 al-representation-social-information-and-new-optogenetic-approach-dissecti
 ng-321888
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