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UID:20251108T092906EST-5930bRIlvT@132.216.98.100
DTSTAMP:20251108T142906Z
DESCRIPTION:There has been significant progress over the last decade in und
 erstanding the molecular basis by which sensory neurons transduce and subs
 equently transmit noxious (ie. tissue damaging) stimuli giving rise to the
  sensation of pain. Over this same period we have recognized that mutation
 s in such ion channels (many of which are selectively expressed in sensory
  neurons) can result in inherited pain disorders in humans. An excellent e
 xample is the voltage gated ion channel NaV 1.7 encoded by the gene SCN9a.
  Loss of function mutations in this ion channel result in congenital inabi
 lity to experience pain due to reduced excitability of nociceptors. Gain o
 f function mutations can cause a number of distinct neuropathic pain disor
 ders including erythromelalgia\, paroxysmal extreme pain disorder and more
  common variants have recently been linked to painful diabetic neuropathy.
  The effects of Nav1.7 are not however restricted to nociceptors as C-low 
 threshold mechanoreceptors also express high levels of Nav1.7. These affer
 ents are implicated in affective touch and indeed although patients with l
 oss of function mutations in Nav1.7 have normal discriminative touch\, aff
 ective touch induced by stroking of hairy skin is impaired. C-LTMR afferen
 ts lacking Nav1.7 show an increased mechanical threshold and altered stimu
 lus response function. In summary Nav1.7 has a dual role: not only is it e
 ssential for pain perception but also affective touch through the regulati
 on of excitability of nociceptors and C-LTMRs respectively.\n\nThis event 
 is co-sponsored by the Alan Edwards Centre for Research on Pain (AECRP) an
 d the Quebec Pain Research Network (QPRN).\n\n \n
DTSTART:20200124T160000Z
DTEND:20200124T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - The role of the voltage gated sodium channel Nav1.7 in hu
 man pain and pleasure
URL:/physiology/channels/event/seminar-role-voltage-ga
 ted-sodium-channel-nav17-human-pain-and-pleasure-303092
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