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UID:20250809T161930EDT-3814aeuw4T@132.216.98.100
DTSTAMP:20250809T201930Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 51łÔąĎÍřUnivers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Edward A F
 on\n\n\nInsights into inter-organelle contact site misregulation in neurod
 egenerative diseases\n\nYvette Wong\n\nPhD\, Assistant Professor of Neurol
 ogy\, Northwestern University Feinberg School of Medicine\, Chicago\, IL\,
  USA\n\nAbstract: Inter-organelle contact sites are important hubs which m
 ediate the direct crosstalk between different organelles\, and their misre
 gulation may play a significant role in the etiology of neurodegenerative 
 disorders including Alzheimer’s disease\, Parkinson’s disease\, ALS\, Fron
 totemporal Dementia and Charcot-Marie-Tooth disease. Using advanced Super-
 Resolution and live imaging approaches\, we recently found that mitochondr
 ia-lysosome contact sites play key roles in regulating the bidirectional c
 rosstalk of mitochondrial and lysosomal dynamics and function. In addition
 \, mitochondria-lysosome contact sites are misregulated in genetic forms o
 f Parkinson’s disease and the peripheral neuropathy Charcot-Marie-Tooth di
 sease. Moreover\, our ongoing studies have identified new roles for the mi
 sregulation of other inter-organelle contact sites in additional neurologi
 cal disorders\, including novel mechanisms regulating TDP-43 in ALS\, and 
 new pathways mediating the crosstalk between amyloid-β and tau in Alzheime
 r’s disease at contact sites. Importantly\, these studies offer new insigh
 ts into disease mechanisms and further highlight the significant role of i
 nter-organelle contacts in neurodegeneration.\n\nDr. Yvette Wong's researc
 h uncovers new cellular functions of inter-organelle contact sites and the
 ir role in neurodegenerative diseases\, utilizing advanced Super-Resolutio
 n live imaging. She received her BA from Cornell University\, with a doubl
 e major in Mathematics and Biology\, and her PhD in Neuroscience from the 
 University of Pennsylvania under the guidance of Dr. Erika Holzbaur\, a Pr
 ofessor of Physiology. During her PhD\, Dr. Wong demonstrated that hunting
 tin regulates autophagosome axonal transport\, identified ALS-associated o
 ptineurin as a mitophagy receptor\, and discovered a new role for actin cy
 cling in mitochondrial dynamics. Following her doctoral studies\, Dr. Wong
  conducted her postdoctoral training with Dr. Dimitri Krainc\, Chair of Ne
 urology at Northwestern University. There\, she identified mitochondria-ly
 sosome contact sites as a crucial hub that is misregulated in Charcot-Mari
 e-Tooth disease and Parkinson’s disease. In 2020\, she established her ind
 ependent research lab at Northwestern University’s Feinberg School of Medi
 cine. Dr. Wong has been the recipient of the NIH K99/R00 Pathway to Indepe
 ndence Award\, the Warren Alpert Scholars Award in Neuroscience\, and the 
 NIH DP2 New Innovator Award.\n
DTSTART:20250930T200000Z
DTEND:20250930T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Killam Seminar Series: Insights into inter-organelle contact site m
 isregulation in neurodegenerative diseases
URL:/neuro/channels/event/killam-seminar-series-insigh
 ts-inter-organelle-contact-site-misregulation-neurodegenerative-diseases-3
 66251
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