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UID:20250626T100908EDT-2316cJ6S6U@132.216.98.100
DTSTAMP:20250626T140908Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 51³Ô¹ÏÍøUnivers
 ity.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, clic
 k here\n\n\nDerek Narendra\n\nInvestigator and Lasker Clinical Research Sc
 holar\, Mitochondrial Biology and Neurodegeneration Unit\, Neurogenetics B
 ranch\, NINDS\, National Institutes of Health (NIH)\n\nHost: gary.armstron
 g [at] mcgill.ca (Gary A.B. Armstrong)\n\nAbstract: Neurodegeneration is a
 n increasing and unmitigated disease burden in our aging population. Among
  its causes are damaged mitochondria that accumulate with age\, particular
 ly in post-mitotic neurons and myocytes. Our group studies monogenic disor
 ders to uncover mitochondrial stress responses that curb mitochondrial dam
 age in neurodegeneration. Our focus includes PINK1 and Parkin\, which form
  a stress-induced mitophagy pathway that targets damaged mitochondria for 
 degradation. Mutations in these genes are the most common recessive forms 
 of Parkinson’s disease\, linking mitophagy to neurodegeneration. We are ad
 ditionally focused on dominant mutations in the paralogs CHCHD2 and CHCHD1
 0\, which cause Parkinson’s disease\, amyotrophic lateral sclerosis\, fron
 totemporal dementia\, and myopathy. In addition to enabling precision ther
 apies for neurogenetic disorders\, our work is uncovering fundamental mito
 chondrial stress responses to mitochondrial damage.\n
DTSTART:20250107T210000Z
DTEND:20250107T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Curbing Mitochondrial Dysfunction in Neurode
 generation: Lessons From Neurogenetics
URL:/neuro/channels/event/killam-seminar-series-curbin
 g-mitochondrial-dysfunction-neurodegeneration-lessons-neurogenetics-362365
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