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UID:20250512T025641EDT-5683Sh8rDZ@132.216.98.100
DTSTAMP:20250512T065641Z
DESCRIPTION:The Feindel Brain and Mind Seminar Series will advance the visi
 on of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1972
 –1984)\, to constantly bridge the clinical and research realms. The talks 
 will highlight the latest advances and discoveries in neuropsychology\, co
 gnitive neuroscience\, and neuroimaging.\n\nSpeakers will include scientis
 ts from across The Neuro\, as well as colleagues and collaborators locally
  and from around the world. The series is intended to provide a virtual fo
 rum for scientists and trainees to continue to foster interdisciplinary ex
 changes on the mechanisms\, diagnosis and treatment of brain and cognitive
  disorders.\n\n\nTo attend in person\, register here\n\nTo watch via Vimeo
 \, click here\n\n\nLydia Chougar\n\nPost-doctoral fellow\, The Neuro\, McG
 ill University\n\nHost: alain.dagher [at] mcgill.ca (Alain Dagher)\n\nAbst
 ract: \n\nParkinson’s disease\, the second most common neurodegenerative d
 isease after Alzheimer’s disease\, is the primary cause of Parkinsonism\, 
 characterized by a combination of resting tremor\, rigidity\, bradykinesia
 \, and postural instability. Atypical Parkinsonism refers to other rare ne
 urodegenerative disorders\, such as progressive supranuclear palsy (PSP)\,
  multiple system atrophy (MSA)\, and corticobasal degeneration\, which are
  associated with a poorer prognosis. Degeneration of the substantia nigra 
 pars compacta is the pathological hallmark of neurodegenerative Parkinsoni
 an disorders. These diseases present significant challenges in terms of ea
 rly diagnosis\, differentiation\, and understanding of their pathophysiolo
 gy.\n\nOver the past twenty-five years\, neuroimaging has profoundly trans
 formed research and clinical management of Parkinsonism. Magnetic resonanc
 e imaging (MRI) provides several in vivo quantitative biomarkers sensitive
  to various tissue properties that reveal underlying pathological processe
 s. Regional brain atrophy\, detected using T1-weighted three-dimensional (
 3D) sequences\, reflects neuronal loss. Diffusion anomalies indicate the p
 resence of microstructural alterations related to neuroinflammation\, whil
 e iron-sensitive imaging detects iron deposits. Neuromelanin-sensitive MRI
  serves as a proxy for degeneration of the substantia nigra. More recently
 \, positron emission tomography (PET) has enabled the detection of misfold
 ed protein aggregates\, such as Tau and alpha-synuclein\, seen in these di
 seases\, allowing for an ante-mortem pathological diagnosis.\n\nThe first 
 part of the talk will illustrate how neuroimaging biomarkers contribute to
  a better understanding of the pathophysiology of Parkinson’s disease and 
 their use in providing an early diagnosis\, quantifying disease severity a
 nd progression\, and monitoring treatment effects. The second part will hi
 ghlight the contribution of neuroimaging to the differential diagnosis of 
 Parkinsonian disorders\, with a focus on recent applications of machine le
 arning algorithms trained with MRI features.\n\n \n
DTSTART:20240916T170000Z
DTEND:20240916T180000Z
LOCATION:De Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Seminar Series: Contribution of MRI to the U
 nderstanding and Diagnosis of Parkinsonism
URL:/neuro/channels/event/feindel-brain-and-mind-semin
 ar-series-contribution-mri-understanding-and-diagnosis-parkinsonism-359469
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