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UID:20250922T150303EDT-1621xgd2Oz@132.216.98.100
DTSTAMP:20250922T190303Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at the MNI and 51³Ô¹ÏÍøUniversit
 y.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, click 
 here\n\n\nJi-Young Youn\, PhD\n\nScientist\, SickKids Research Institute\,
  Assistant Professor\, University of Toronto\, Canada\n\nHost: gary.armstr
 ong [at] mcgill.ca (Gary Armstrong)\n\nAbstract: Amyotrophic lateral scler
 osis (ALS) is a neurodegenerative disease with no known cure. A hallmark o
 f ALS is the cytoplasmic aggregation of TAR DNA-binding protein 43 (TARDBP
 \, called TDP-43 here). TDP-43 is an essential DNA/RNA-binding protein wit
 h multiple roles in post-transcriptional regulation. Harboring prion-like 
 domain\, TDP-43 readily phase separates in vitro and localizes to biomolec
 ular condensates formed by cellular phase separation. Aberrant phase trans
 ition of TDP-43\, accelerated by ALS-associated mutations or stress\, are 
 thought to underly ALS pathogenesis. However\, the functional consequences
  of altering TDP-43 phase separation properties remain poorly understood. 
 In this talk\, I will share our efforts to characterize ALS-associated TDP
 -43 variants with altered phase separation dynamics. Exploiting proximity-
 dependent biotinylation techniques\, we examine quantitative changes in pr
 oximal interaction networks of TDP-43 variants or TDP-43 wildtype during s
 tress. Our preliminary data reveal unanticipated functions of TDP-43 contr
 olled by phase separation.\n
DTSTART:20240227T210000Z
DTEND:20240227T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Chasing Shape-Shifting Condensates Linked to
  ALS with Proteomics
URL:/neuro/channels/event/killam-seminar-series-chasin
 g-shape-shifting-condensates-linked-als-proteomics-355223
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