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DTSTAMP:20250623T021815Z
DESCRIPTION:Register here.\n\nStream via vimeo here.\n\n\nKamil Uludag\n\nK
 oerner Scientist\, Krembil Brain Institute\, Canada\n\nAbstract: In this t
 alk\, I will provide an overview of the physiological processes that contr
 ibute to the observed BOLD signal (i.e.\, the generative biophysical model
 )\, including their time course properties within the framework of the phy
 siologically-informed dynamic causal modeling (P-DCM). Specifically\, the 
 physiological origin of the so-called BOLD signal “transients” will be dis
 cussed\, including the initial overshoot\, steady-state activation and the
  post-stimulus undershoot. I argue that incorrect physiological assumption
 s in the generative model of the BOLD signal can lead to incorrect inferen
 ces pertaining to both local neuronal activity and effective connectivity 
 between brain regions. In addition\, I introduce the recent laminar BOLD s
 ignal model\, which extends P-DCM to cortical depths-resolved BOLD signals
 \, allowing for laminar neuronal activity to be determined using high-reso
 lution fMRI data. Finally\, I outline a research program to leverage the B
 igBrain to develop brain-area specific microcircuit models\, which can rep
 resent the neuronal component of the laminar fMRI signal model.\n\nBio: Kâ
 mil Uludağ studied from 1992 till 1997 Physics at the Technical University
  of Berlin. He completed his Ph.D. in Physics in 2003 on Near-Infrared Opt
 ical Spectroscopy (Humboldt University\, Berlin) and moved for a postdoc p
 osition to the Center for Functional MRI (UCSD\, San Diego\, USA) to work 
 on the physiological and physical basis of functional MRI. In 2004\, he wa
 s appointed Head of Human Brain Imaging group at the Max-Planck-Institute 
 for Biological Cybernetics\, Tübingen. From June 2010 to December 2018\, h
 e was Associate Professor in the Faculty of Psychology & Neuroscience and 
 Head of the Department of Cognitive Neuroscience continuing his work on th
 e basis of fMRI utilizing the new Ultra-High Field human MRI scanners (7 a
 nd 9.4 Tesla). Since 2019\, he is Senior Scientist at the University Healt
 h Network (UHN) and Full Professor at the Department of Medical Biophysics
 \, University of Toronto.\n\nDr. Uludağ is on the editorial board of sever
 al neuroimaging journals\, served from 2011 to 2013 as Annual Meeting Comm
 ittee Member of the International Society for Magnetic Resonance Imaging i
 n Medicine (ISMRM) and was elected Chair of the Current Issues of Brain Fu
 nction study group. He recently edited a textbook “functional MRI: from Nu
 clear Spins to Brain Functions” (Publisher: Springer).\n\n\nThe Feindel Br
 ain and Mind Seminar Series will advance the vision of Dr. William Feindel
  (1918–2014)\, Former Director of the Neuro (1972–1984)\, to constantly br
 idge the clinical and research realms. The talks will highlight the latest
  advances and discoveries in neuropsychology\, cognitive neuroscience\, an
 d neuroimaging.\n\nSpeakers will include scientists from across The Neuro\
 , as well as colleagues and collaborators locally and from around the worl
 d. The series is intended to provide a virtual forum for scientists and tr
 ainees to continue to foster interdisciplinary exchanges on the mechanisms
 \, diagnosis and treatment of brain and cognitive disorders.\n\n \n
DTSTART:20230411T173000Z
DTEND:20230411T183000Z
LOCATION:De Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Seminar Series: Bridging the gap between Big
 Brain and functional MRI in humans using biophysical generative models
URL:/neuro/channels/event/feindel-brain-and-mind-semin
 ar-series-bridging-gap-between-bigbrain-and-functional-mri-humans-using-34
 7404
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