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DESCRIPTION:\nTo watch in person\, register here.\n\nTo watch on Vimeo\, cl
 ick here.\n\n\nKuldeep Kumar\n\nPostdoctoral Fellow\, CHU Sainte-Justine R
 esearch Centre\, University of Montreal\, Canada\n\n\nAbstract: Cognitive 
 ability is subserved by large-scale brain networks. Previous research has 
 established a relationship between normative spatial patterns of gene expr
 ession across the cortex\, and the neuroanatomical as well as the function
 al organization of the cortex. However\, the relationship between variatio
 ns in gene expression across the cortex and cognitive ability has not yet 
 been systematically investigated. In this talk\, I will focus on how copy 
 number variants (CNVs)\, which are genomic deletions or duplications and f
 ully encompass one or more genes\, offer a unique opportunity to character
 ize the impact of inter-individual genetic variation on cognitive ability.
  Using one of the largest aggregated data with CNV calls and measures of c
 ognitive ability\, we map the effects of CNVs on cognitive ability across 
 the human cortex. The deletion and duplication effect size maps show posit
 ive and negative correlations with the established hierarchical gradient o
 f the cortical organization. Our findings suggest that mutations with oppo
 sing gene dosage alter cognitive ability when they affect genes with oppos
 ing spatial patterns of expression in the cortex\, suggesting that there i
 s an optimal balance of gene expression across large-scale brain networks.
 \n\nBio: Kuldeep Kumar is a postdoctoral fellow in the lab of Prof. Sébast
 ien Jacquemont at the CHU Sainte-Justine Research Centre at the University
  of Montreal in Canada. He is studying how rare genetic variations can aff
 ect how the brain works and its structure. Kuldeep previously earned a Ph.
 D. from ETS Montreal\, Canada\, under the supervision of Professor Christi
 an Desrosiers\, where he used multi-modal MRI data to obtain brain fingerp
 rints for individual subject characterization. Prior to that\, he graduate
 d in Electronics engineering from the Indian Institute of Technology Khara
 gpur\, India\, and worked as a scientist in the Indian Space Research Orga
 nization (ISRO). His research interests include imaging genetics\, medical
  image analysis\, and neuroscience. He used to play hockey\, the one on th
 e grass and not on the ice. \n\n\nThe Feindel Virtual Brain and Mind (VBM)
  Seminar Series will advance the vision of Dr. William Feindel (1918–2014)
 \, Former Director of the Neuro (1972–1984)\, to constantly bridge the cli
 nical and research realms. The talks will highlight the latest advances an
 d discoveries in neuropsychology\, cognitive neuroscience\, and neuroimagi
 ng.\n\nSpeakers will include scientists from across The Neuro\, as well as
  colleagues and collaborators locally and from around the world. The serie
 s is intended to provide a virtual forum for scientists and trainees to co
 ntinue to foster interdisciplinary exchanges on the mechanisms\, diagnosis
  and treatment of brain and cognitive disorders.\n
DTSTART:20230201T210000Z
DTEND:20230201T220000Z
SUMMARY:Feindel Virtual Brain and Mind Lecture Series:Genomic deletions and
  duplications show effects on cognitive ability along the hierarchical gra
 dient of the cortical organization
URL:/neuro/channels/event/feindel-virtual-brain-and-mi
 nd-lecture-seriesgenomic-deletions-and-duplications-show-effects-345580
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