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DESCRIPTION:\nThe Feindel Virtual Brain and Mind Seminar presents: 'Linking
  microscopy-derived microstructure to MRI signals throughout the macaque b
 rain'\n\nAmy Howard\, Postdoctoral researcher\, Diffusion MRI\, University
  of Oxford\, UK\n\n\nAbstract: Understanding brain structure and function 
 often requires combining data across different modalities and scales to li
 nk microscale cellular structures to macroscale features of whole brain or
 ganisation. Here we introduce the BigMac dataset\, a resource combining in
  vivo MRI\, extensive postmortem MRI and multi-contrast microscopy for mul
 timodal characterisation of a single whole macaque brain. The data spans m
 odalities (MRI and microscopy)\, tissue states (in vivo and postmortem)\, 
 and four orders of spatial magnitude\, from microscopy images with microme
 tre or sub-micrometre resolution\, to MRI signals on the order of millimet
 res. Crucially\, the MRI and microscopy images are carefully co-registered
  together to facilitate quantitative multimodal analyses. In this talk I w
 ill detail the acquisition\, curation\, and first release of the data\, th
 at together make BigMac a unique\, openly-disseminated resource available 
 to researchers worldwide. Further\, I will demonstrate example analyses an
 d opportunities afforded by the data\, including improvement of connectivi
 ty estimates from ultra-high angular resolution diffusion MRI\, neuroanato
 mical insight provided by polarised light imaging and myelin-stained histo
 logy\, and the joint analysis of MRI and microscopy data for reconstructio
 n of the microscopy-inspired connectome.\n\nBio: Amy Howard is a Postdocto
 ral Researcher at the Wellcome Centre for Integrative Neuroimaging\, Unive
 rsity of Oxford\, where she also completed her PhD. Amy’s research conside
 rs different ways in which we can combine complementary data from both mic
 roscopy and diffusion MRI\, to both validate and drive biophysical modelli
 ng of the brain tissue microstructure.\n\n\n\nThe Feindel Virtual Brain an
 d Mind (VBM) Seminar Series will advance the vision of Dr. William Feindel
  (1918–2014)\, Former Director of the Neuro (1972–1984)\, to constantly br
 idge the clinical and research realms. The talks will highlight the latest
  advances and discoveries in neuropsychology\, cognitive neuroscience\, an
 d neuroimaging.\n\nSpeakers will include scientists from across The Neuro\
 , as well as colleagues and collaborators locally and from around the worl
 d. The series is intended to provide a virtual forum for scientists and tr
 ainees to continue to foster interdisciplinary exchanges on the mechanisms
 \, diagnosis and treatment of brain and cognitive disorders.\n\n\nTo watch
  via Vimeo\, click here.\n
DTSTART:20221116T210000Z
DTEND:20221116T220000Z
LOCATION:De Grandpre Communications Center\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Lecture Series: Linking microscopy-derived m
 icrostructure to MRI signals throughout the macaque brain
URL:/neuro/channels/event/feindel-brain-and-mind-lectu
 re-series-linking-microscopy-derived-microstructure-mri-signals-342385
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