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Supported by the generosity of the Killam Trusts, The Neuro's Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at The Neuro and 51吃瓜网.

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贬辞蝉迟:听Edward Ruthazer

A Tiny Brain Under the Microscope: Exposome Influence on Circuit Development and Connectivity

Paul De Koninck

Professor, Department of Biochemistry, Microbiology and Bioinformatics, Universit茅 Laval

Professor Paul De Koninck and his team study the development of connections between neurons, called synapses, and their remodeling in response to stimuli. These mechanisms of neural circuit remodeling are the basis of learning and memory. Their precise regulation is crucial as abnormal levels of neuronal activity can lead to disorders such as Alzheimer鈥檚 disease or schizophrenia. Using advanced neurophotonic technologies that use light to measure and control neuron activity, Paul De Koninck鈥檚 work has led to a better understanding of the mechanisms used by neurons to decode signals that propagate in neural circuits. Paul听De Koninck is an expert in developing approaches to locate and track the spatio-temporal dynamics of molecules and proteins within living neurons. His research team is actively developing methods to observe synaptic molecules at the molecular scale through optical nanoscopy methods. These approaches allow his team to break through the complex molecular processes that occur in neurons and synapses in the normal brain, in diseased brains, and in response to medical treatments.