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Supported by the generosity of the Killam Trusts, The Neuro's Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at The Neuro and 51吃瓜网.

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贬辞蝉迟:听Sridar Narayanan

7T MRI for Multiple Sclerosis: Insights into Pathology and Future Directions

Daniel M. Harrison

Professor and Vice Chair for Research, Department of Neurology, University of Maryland School of Medicine; Director, University of Maryland Center for Multiple Sclerosis Treatment and Research

Abstract:听Ultra-high field, 7 Tesla (7T) MRI has provided a powerful in vivo tool for understanding the pathophysiology of multiple sclerosis (MS) and the clinical impact of pathologic changes. This tool holds additional promise as a method for improve diagnostics, treatment efficacy monitoring, and as an outcome measure for clinical trials. In this talk, we will accomplish the following objectives: 1. To review contributions of 7T MRI to our understanding of the impact of cortical and deep gray matter and chronic active white matter lesions 2. To review 7T MRI methods for measuring blood brain barrier breakdown and meningeal/lymphatic pathology 3. To discuss further work necessary to move forward with clinical translation of 7T MRI for multiple sclerosis

Dr. Harrison is a Professor of Neurology at the University of Maryland School of Medicine. Dr. Harrison directs an active research program focused on the development and validation of new techniques for imaging of the central nervous system for application to multiple sclerosis research and clinical trials. Dr. Harrison's research program is currently focused on utilization of novel MRI techniques, including high-field, 7-tesla MRI for visualization of cortical pathology, neurodegeneration, and meningeal inflammation in multiple sclerosis. His lab also works on utilization of novel imaging techniques of the retina and visual pathways in MS and on machine learning based approaches to image analysis and outcomes prediction. Dr. Harrison's research program is supported by multiple NIH, Department of Defense, National MS Society, and industry grants. Dr. Harrison is also an active investigator in the Maryland Center for MS clinical trials program. Dr. Harrison received a Bachelor of Arts Degree with Highest Honors in Biology from Rutgers University after which he received a Medical Doctorate from the Albert Einstein College of Medicine. He went on to train in neurology in the residency program at Columbia University Medical Center, followed by a fellowship in neuroimmunology and neuroinfectious disease at the Johns Hopkins University School of Medicine. He was on faculty at Johns Hopkins from 2010 until 2015, after which he took a position at the University of Maryland. He became Director of the MS Center in 2018 and Vice Chair for Research in the Department of Neurology in 2024.