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UID:20250627T163642EDT-7066AoKNxe@132.216.98.100
DTSTAMP:20250627T203642Z
DESCRIPTION:PHYSIOLOGICAL MINERALIZATION IS A DELICATELY ORCHESTRATED PROCE
 SS necessary for healthy tissue function\, as seen in bone and tooth forma
 tion. Sometimes\, however\, mineral deposits form in tissues that should n
 ot have mineral. This process of pathological mineralization is associated
  with a wide range of diseases and tissue types\, including the cardiovasc
 ular system and the tumor microenvironment of multiple types of cancer. Fr
 om decades of study of physiological biomineralization mechanisms\, it is 
 generally accepted that the formation of mineralized tissues and the resul
 ting structure-function relationships in those tissues are controlled by t
 he interplay among the mineral\, matrix\, and cells. The goal of Prof. Est
 off and her team's work is to characterize the mineral-matrix-cell triad o
 f pathological mineral deposits and develop in vitro models that recapitul
 ates key aspects of pathological mineralization in a range of systems. The
 y focus on two examples of pathological mineralization: microcalcification
 s (MCs)\, which are primarily biological apatite and occur in cancerous an
 d benign breast pathologies\, and calcific aortic valve disease (CAVD)\, i
 n which mineralized lesions form in the leaflets of the aortic valve\, inh
 ibiting proper function. They have developed an omics-inspired approach\, 
 by which we define “biomineralogical signatures” by combining materials me
 trics derived from Raman microscopy and energy dispersive spectroscopy for
  individual mineral deposits.\n\nLARA A. ESTROFF is a Professor in the Mat
 erials Science and Engineering department at Cornell University and the He
 rbert Fisk Johnson Professor of Industrial Chemistry. She is the current C
 hair of the Materials Science and Engineering department. Her group focuse
 s on bio-inspired materials synthesis\, crystal growth mechanisms\, and th
 e high-resolution characterization of pathological mineralization. She has
  received several awards\, including an NSF Early Faculty Career Award in 
 2009 and a J.D. Watson Young Investigator’s award from NYSTAR in 2006.\n
DTSTART:20250402T150000Z
DTEND:20250402T160000Z
LOCATION:FDA Room 3\, Adams Building\, CA\, QC\, Montreal\, H3A 0E8\, 3450 
 rue University
SUMMARY:Biomineralogical Signatures of Pathological Mineralization - Lara A
 . Estroff
URL:/miam/channels/event/biomineralogical-signatures-p
 athological-mineralization-lara-estroff-364408
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