Special Seminar: Selective Neuronal Vulnerability in Neurodegenerative Diseases
Special Seminar
Selective Neuronal Vulnerability in Neurodegenerative Diseases
Serge Przedborski, MD, PhD
Departments of Neurology, Pathology, Cell Biology, and Neuroscience
Columbia University, New York
In person: de Grandpr茅 Communications Centre听
翱苍濒颈苍别:听
Dr. Przedborski is an internationally recognized leader in the field of neurodegenerative disorders, with core research interests focused on the molecular and cellular pathology of Parkinson鈥檚 Disease (PD) and Amyotrophic Lateral Sclerosis (ALS). His laboratory systematically investigates the complex roles of both cell-autonomous and non-cell-autonomous mechanisms in neurodegeneration, focusing on differential neuronal susceptibility. This is achieved using a combination of toxic and genetic models, as well as postmortem tissues from PD and ALS patients.
Key ongoing research areas include:
- Mitochondrial Biology: A primary focus is to understand how mitochondrial dysfunction and altered communication with other organelles, such as the endoplasmic reticulum, contribute to cellular perturbations, including lipid dyshomeostasis, and ultimately lead to the degeneration of specific neuronal subpopulations.
- Non-Neuronal Cell Contributions: Another key line of inquiry explores the extent to which non-neuronal cells, such as astrocytes and microglia, participate in the degeneration of neighboring neurons.
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Dr. Przedborski鈥檚 standing in the field is evidenced by his significant editorial and review service to the global scientific community; he holds editorial positions, serving as an Associate Editor for the NPJ Parkinson鈥檚 Disease and as a Reviewing Editor for eLife. Furthermore, his expertise is routinely sought by top-tier funding agencies and publications, including his service as a reviewer for the National Institutes of Health (NIH), the Canadian Medical Research Council, and high-impact journals such as Science, Nature, Nature Neuroscience, Neuron, the New England Journal of Medicine, and the Proceedings of the National Academy of Sciences USA.
