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UID:20251106T032754EST-2101zwiuu5@132.216.98.100
DTSTAMP:20251106T082754Z
DESCRIPTION:Patient‐derived models of breast cancer and functional oncology
 \n\nBryan E. Welm\, PhD\n	Associate Professor\n	Department of Surgery\n	Inves
 tigator\n	Huntsman Cancer Institute\n	University of Utah\n\nThe goal of the 
 Welm Lab is to develop and utilize patient-derived models\, including xeno
 grafts (PDX) and organoids (PDO)\, for functional precision oncology and p
 reclinical cancer research. The hypothesis is that patient-derived models 
 maintain salient molecular and genomic features of tumors\, and when studi
 ed co-clinically\, will enable patients to be better matched with effectiv
 e therapies. The Welm lab has established a bank of PDO models that are us
 ed in moderate throughput screens of FDA-approved and NCI Investigational 
 New Drugs. Effective “lead” therapies observed in the organoid assay are t
 hen validated in vivo using PDX models predicted to be responders or non-r
 esponder. For each lead therapy\, genomic data are utilized to identify pr
 oteomic\, gene expression and/or mutational signatures associated with dru
 g response. In addition\, a clinical study is being performed to evaluate 
 the feasibility of functional precision oncology for breast cancer patient
 s. PDX and PDO models are generated from newly diagnosed TNBC patients\, a
 nd their models are tested against a library of 50 cancer drugs. The model
 s and patient tumors are also analyzed for genomic variants and gene expre
 ssion profiles\, which are used to identify targeted therapies that may be
  effective against the patient’s tumor. The goal is to evaluate the feasib
 ility of determining drug sensitivity profiles of patient-derived models w
 ithin a clinically-relevant timeframe\, and to determine the actionability
  of these data within a clinical setting.\n
DTSTART:20191002T200000Z
DTEND:20191002T210000Z
LOCATION:Martin Amphitheatre\, Room 504\, McIntyre Medical Building\, CA\, 
 QC\, Montreal\, H3G 1Y6\, 3655 promenade Sir William Osler
SUMMARY:GCRC Frontiers in Cancer Research Lecture Series
URL:/medhealthsci/channels/event/gcrc-frontiers-cancer
 -research-lecture-series-301033
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