BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250507T103140EDT-3730uPlG5V@132.216.98.100 DTSTAMP:20250507T143140Z DESCRIPTION: \nA word of caution regarding stabilized weights when using ma rginal structural models to estimate the effect of exposure history\nDenis Talbot\, PhD\n Biostatistics Professor\, Department of Social and Preventi ve Medicine\, Laval University\n\n Abstract:\nMarginal structural models (M SMs) are commonly used to estimate the causal effect of a time-varying exp osure in presence of time-dependent confounding. These models have gained vast popularity over the recent years\, in part due to their ease of imple mentation. Indeed\, the most common implementation of MSMs consists of fit ting a weighted outcome model (e.g. a linear regression)\, where observati ons are weighted according to their inverse-probability-of-treatment weigh ts. Users must however be wary of a number of subtle issues regarding MSMs that might impact the validity of the inferences. In this talk\, I first introduce MSMs and then present one such issue: the stabilization of the w eights. This stabilization is usually recommended to reduce variability\, but I provide a simple example and some simulation results where it is als o observed to yield biased inferences.\nBio:\nhttps://sites.google.com/sit e/denistalbotfmed1/home\n DTSTART:20150922T193000Z DTEND:20150922T203000Z LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue des Pins Ouest SUMMARY:Biostatistics Seminar URL:/epi-biostat-occh/channels/event/biostatistics-sem inar-254824 END:VEVENT END:VCALENDAR