BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250801T150651EDT-2125WIe43G@132.216.98.100
DTSTAMP:20250801T190651Z
DESCRIPTION:EPIDEMIOLOGY SEMINAR SERIES - Fall 2015\n\nBrent Richards\, PhD
 \n\nAssociate Professor\, William Dawson Scholar & FRQS Chercheur Boursier
  Clinician Scientist\, Lady Davis Institute\, Jewish General Hospital\, Mc
 Gill University and a Senior Lecturer\, King’s College London\, UK\n\nDoes
  Vitamin D Insufficiency Influence Common Disease? Results from Mendelian 
 Randomization Studies\n\nALL ARE WELCOME\n\nSYNOPSIS:\n\nVitamin D insuffi
 ciency has been linked in epidemiological studies to numerous common disea
 ses\, including multiple sclerosis\, type 1 diabetes\, coronary heart dise
 ase\, several cancers\, stroke and osteoporosis. However\, vitamin D is a 
 heavily confounded biomarker and is also prone to reverse causation since 
 sick people tend to stay inside more\, and as a result\, have lower vitami
 n D levels. We have undertaken large-scale Mendelian randomization studies
 \, which greatly diminish the influence of confounding and reverse causati
 on to test whether vitamin D insufficiency may be involved in the causal p
 athway for these diseases. We have identified strong influences of genetic
 ally lowered vitamin D levels on risk of MS and little to no effect on mos
 t other diseases. I will also discuss challenges and opportunities in tran
 slating these findings to clinical care.\n\nOBJECTIVES:\n\n\n	To understand
  the design of Mendelian randomization studies\n	To understand the limitati
 ons of Mendelian randomization studies\n	To understand the role of vitamin 
 D in common\, complex disease\n\n\nBIO:\n\nBrent Richards is an Associate 
 Professor\, William Dawson Scholar and FRQS Chercheur Boursier Clinician S
 cientist\, at the Lady Davis Institute of the Jewish General Hospital\, at
  51³Ô¹ÏÍø and a Senior Lecturer at King’s College London\, UK. Tr
 ained in genetics\, clinical medicine\, endocrinology\, epidemiology and b
 iostatistics through support from the Canadian Institutes of Health Resear
 ch\, a Commonwealth Scholarship and Osteoporosis Canada\, Dr. Richards foc
 uses on understanding the genetic determinants of common aging-related end
 ocrine diseases\, such as osteoporosis and diabetes. He and his colleagues
  have made important advances by identifying the genes that cause these di
 seases and actively engages with pharmaceutical companies to translate the
 se findings to improved clinical care. Currently he co-chairs the world’s 
 largest whole-genome sequencing program for common disease and has recentl
 y identified a novel and central protein critical to skeletal formation an
 d fracture risk through the studying over half a million research subjects
  around the world. His work has been recognized through a CIHR Clinician S
 cientist award\, a CIHR Maud Menten award for research excellence in Human
  Genetics\, and a CIHR/Canadian Society of Endocrinology and Metabolism Yo
 ung Investigator Award for excellence in endocrine research.\n\nwww.mcgill
 .ca/epi-biostat-occh/news-events/seminars/epidemiology\n
DTSTART:20151019T200000Z
DTEND:20151019T210000Z
LOCATION:Room 521\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y
 6\, 3655 promenade Sir William Osler
SUMMARY:Epidemiology Seminar
URL:/epi-biostat-occh/channels/event/epidemiology-semi
 nar-255480
END:VEVENT
END:VCALENDAR