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UID:20250625T070900EDT-5181bSNf9b@132.216.98.100
DTSTAMP:20250625T110900Z
DESCRIPTION:Metal complexes have gained a growing interest as pharmaceutica
 ls for their use as diagnostic agents or as chemotherapeutic drugs. In our
  group some efforts have been done in the development of anticancer agents
  employing essential metals such as the family of copper (II) compounds kn
 own as Casiopeínas®\, with a general formula [Cu (N-N) (X-Y) H2O] NO3 wher
 e N-N is a diimine (phen or bipy) and X-Y is a bidentate ligand (acac\, sa
 lal\, aminoacidate\, peptide\, benzimidazol). These compounds have shown c
 ytostatic\, cytotoxic and antineoplastic activity in vitro and in vivo. Co
 mparison between first and second generation of casiopeina´s activity is p
 resented. Also albumin/Casiopeinas interaction is discussed.\n	The mechanis
 m of action is still not completely elucidated. However\, experimental evi
 dence suggests the interaction of coordination compounds with DNA (nuclear
  or mitochondrial) and their components and the generation of reactive oxy
 gen species (ROS) as the main action pathways. Induction of apoptosis has 
 been proved to be the main death tumoral cell pathway.\n	DNA interaction ha
 s been done by several methods\, comet assay\, AFM\, electrophoresis\, CD 
 and the nuclease activity studies of 4 Casiopeínas® employing plasmidic DN
 A in several reaction conditions is presented\, microarray.\n	Comparison of
  the results shown that compounds with 4\,7-dimethyl phenanthroline in the
  copper (II) coordination sphere have an extraordinary DNA cleavage capaci
 ty\, compared with the 4\,4´-diimine analogs\, then is suggested a interca
 lation process as the first step for the DNA damage. Also calculations hav
 e been done in order to modeling the interaction between Casiopeínas and D
 NA.\n	Also a new synthetic pathway was reported to obtain N6 donor ligand 2
 \,9-Bis-(2’\,5’-diazahexanyl)-1\,10-phenanthroline (L1) and its coordinati
 on compounds of essential divalent\n
DTSTART:20150619T170000Z
DTEND:20150619T181500Z
LOCATION:Room 328\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8
 \, 801 rue Sherbrooke Ouest
SUMMARY:Chemistry Seminar: Lena Ruiz-Azuara: Overview of Antitumor and anti
 parasitary metallodrugs: Activity and mechanism of action
URL:/chemistry/channels/event/chemistry-seminar-lena-r
 uiz-azuara-overview-antitumor-and-antiparasitary-metallodrugs-activity-and
 -253482
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