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UID:20250513T130042EDT-2359vtKrK2@132.216.98.100
DTSTAMP:20250513T170042Z
DESCRIPTION:Abstract:\n\nA longstanding goal in neuroscience is to understa
 nd how spatiotemporal patterns of neuronal electrical activity underlie br
 ain function\, from sensory representations to decision-making. An emergin
 g technology for monitoring electrical dynamics is voltage imaging using G
 enetically Encoded Voltage Indicators (GEVIs) — light-emitting protein ind
 icators whose brightness is modulated by voltage. GEVIs are promising tool
 s for monitoring voltage dynamics at high spatiotemporal resolution in gen
 etically defined cell types. However\, current indicators enable a narrow 
 range of applications in vivo due to poor performance under two-photon mic
 roscopy\, a method of choice for deep-tissue recording. Using a novel high
 -throughput screening platform\, we developed JEDI-2P\, an indicator that 
 is faster\, brighter\, and more sensitive and photostable than its predece
 ssors. We demonstrate that JEDI-2P can optically record the voltage dynami
 cs of individual cortical neurons in awake behaving mice for more than 30 
 minutes using two-photon resonant scanning and random-access microscopy.\n
 \n \n\nBio:\n\nFrançois St-Pierre received a B.A. and M.A. in the Natural 
 Sciences from the University of Cambridge\, UK. He then attended the Massa
 chusetts Institute of Technology to work with Drew Endy\, receiving a PhD 
 in Computational and Systems Biology in 2009. He then moved to Stanford Un
 iversity and worked in the Laboratory of Michael Z. Lin as a postdoctoral 
 fellow. He is now an Assistant Professor & McNair Scholar in the Departmen
 t of Neuroscience at Baylor College of Medicine and in the Electrical and 
 Computer Engineering Department at Rice University. His research integrate
 s synthetic biology\, protein engineering\, and high throughput imaging to
  advance neuroscience research.\n
DTSTART:20221004T170000Z
DTEND:20221004T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Francois St-Pierre - Evolved fluorescent 
 indicators to monitor neuronal voltage dynamics in vivo
URL:/chemistry/channels/event/chemical-society-seminar
 -francois-st-pierre-evolved-fluorescent-indicators-monitor-neuronal-voltag
 e-340119
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