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DTSTAMP:20250816T153430Z
DESCRIPTION:Abstract:\n\nWe have developed a family of selective organic ca
 talysts for ring-opening polymerization reactions\,1 and have integrated t
 hese catalysts into flow reactors for the programmed synthesis of block co
 polymer libraries.2 In parallel efforts\, we have developed aerobic alcoho
 l oxidation catalysts3 that generate new monomers which were then enchaine
 d using organocatalytic polymerization4 to generate functional materials t
 hat proved useful agents for the delivery of messenger RNA into living ani
 mals.4-7 Functional delivery of messenger RNA (mRNA) in-vivo is key to imp
 lementing potentially transformative strategies for vaccination\, protein 
 replacement therapy and genome editing. The step-economical synthesis and 
 evaluation of a new\, tunable and effective class of synthetic biodegradab
 le materials: Charge-Altering Releasable Transporters (CARTs) will be desc
 ribed for mRNA delivery. CARTs are structurally unique and operate through
  an unprecedented mechanism\, serving initially as oligo(α-amino ester) ca
 tions that complex\, protect and deliver mRNA\, and then change physical p
 roperties through a degradative\, charge-neutralizing intramolecular rearr
 angement\, leading to intracellular release of functional mRNA and highly 
 efficient protein expression.\n\n(1) Lin\, B.\; Waymouth\, R. M. 'Urea Ani
 ons: Simple\, Fast\, and Selective Catalysts for Ring-Opening Polymerizati
 ons' J. Am. Chem. Soc.\, 2017\, 139(4)\, 1645–1652\n\n(2) Lin\, B.\; Hedri
 ck\, J. L.\; Park\, N. H.\; Waymouth\, R. M. 'A Programmable High-Throughp
 ut Platform for the Rapid and Scalable Synthesis of Polyester and Polycarb
 onate Libraries' J. Am. Chem. Soc\, 2019\, 141\,8921-8927.\n\n(3) Ho\, W. 
 C.\, Chung\, K.\; Ingram\, A. J.\, Waymouth\, R. M. 'Pd-Catalyzed Aerobic 
 Oxidation Reactions: Strategies to Increase Catalyst Lifetimes'\, J. Am. C
 hem. Soc.\, 2018\, 140\, 748-757\n\n(4) Blake\, T.\; Waymouth\, R. M. ' Or
 ganocatalytic Ring Opening Polymerization of Morpholinones: New Strategies
  to Functionalized Polyesters ' J. Am. Chem. Soc.\, 2014\, 136\, 9252-9255
 .\n\n(5) McKinlay\, C. J.\; Vargas\, J. R.\; Blake\, T. R.\; Hardy\, J. W.
 \; Kanada\, M.\; Contag\, C. H.\; Wender\, P. A.\; Waymouth\, R. M. 'Charg
 e-altering Releasable Transporters (CARTs) for the delivery and release of
  messenger RNA in living animals' Proc. Natl. Acad. Sci.\, 2017\, 114\, E4
 48-E456.\n\n(6) Haalbeth\, O.\; Blake\, T.\; McKinlay\, C. J.\; Waymouth\,
  R. M.\; Wender\, P. A.\; Levy\, R.\; 'Vaccination with Charge-Altering Re
 leasable Transporters of mRNA Cures Established Experimental Tumors' Proc.
  Nat. Acad. Sci.\, 2018\, 115(39) E9153-E9161\n\n(7) Haabeth\, O. A. W.\; 
 Blake\, T. R.\; McKinlay\, C. J.\; Tveita\, A.\; Sallets\, A.\; Waymouth\,
  R.M.\; Wender\, P. A.\; Levy\, R. 'Local OX40L\, CD80\, and CD86 mRNA del
 ivery kindles global anti-cancer immunity.' Cancer Res 2019\, 79 (7)\, 162
 4-1634.\n\nBio:\n\nRobert Waymouth is the Robert Eckles Swain Professor of
  Chemistry at Stanford University. He received B.S. in Mathematics and B.A
 . in Chemistry from Washington and Lee University and his Ph.D. in Chemist
 ry at the Caltech in 1987 with Professor R.H. Grubbs. He was a postdoctora
 l fellow with the late Professor Piero Pino at the ETH in Zurich in 1987 a
 nd joined the faculty at Stanford as an Assistant Professor in 1988. He re
 ceived the Alan T. Waterman Award from the NSF in 1996\, the Cooperative R
 esearch Award in Polymer Science in 2009\, and EPA's Presidential Green Ch
 emistry Challenge Award in 2012 with Dr. James Hedrick. He has won several
  university teaching awards\, including the Walter J. Gores Award\, the Ph
 i Beta Kappa Teaching Award\, and is currently a Bass Fellow in Undergradu
 ate Education. His research interests are at the interface of Inorganic\, 
 Organic and Polymer Chemistry\, in particular the development of new conce
 pts in catalysis for the selective synthesis of both macromolecules and fi
 ne chemicals. Particular areas of interest include catalytic polymerizatio
 n reactions\, selective oxidation catalysis the development of organocatal
 ytic polymerization strategies and the design of functional macromolecules
  for applications in biology and medicine.\n
DTSTART:20190917T170000Z
DTEND:20190917T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Allan Hay Memorial Lecture: Robert Waymouth - Organocatalytic Polym
 erization: From Chemistry to Biology
URL:/chemistry/channels/event/allan-hay-memorial-lectu
 re-robert-waymouth-organocatalytic-polymerization-chemistry-biology-299515
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