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PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
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UID:20251110T023010EST-79527wSuVV@132.216.98.100
DTSTAMP:20251110T073010Z
DESCRIPTION:Abstract:\n\nDNA exists as single molecules in individual cells
 . Genomic variations such as copy-number variations (CNVs) and single nucl
 eotide variations (SNVs) in a single cell occur in a stochastic way\, nece
 ssitating single-cell and single-molecule measurements to be identified. H
 owever\, existing single-cell whole genome amplification (WGA) methods are
  limited by low accuracy of CNV and SNV detection. We have developed trans
 posase-based methods for single-cell WGA\, which have superseded previous 
 methods.\n\nWith the improved genome coverage of our new WGA method\, we h
 ave also developed a high-resolution single-cell chromatin conformation ca
 pture method\, which allows for the first 3D genome map of a human diploid
  cell.\n\nGene expression is also stochastic due to the fact that the DNA 
 exists as single-molecules in individual cells. The correlations among dif
 ferent mRNAs in a single-cell are masked within the stochastic gene expres
 sion noise. We have developed a method for single-cell transcriptome with 
 improved detection efficiency and accuracy\, revealing intrinsic correlati
 ons among all detected mRNAs in a single-cell. For a particular human cell
  type\, we uncovered ~148 transcriptionally correlated modules (TCMs) from
  the gene expression data of ~1000 individual cells under a steady state c
 ondition. We found that the TCMs are cell type dependent.\n\nBio:\n\nProfe
 ssor Xiaoliang Sunney Xie is an internationally renowned biophysical chemi
 st\, and the Lee Shao-kee professor of Peking University. After a career a
 t Pacific Northwest National Laboratory\, he became the first tenured prof
 essor at Harvard University among Chinese scholars who went to the US sinc
 e the Reform in China. As a pioneer of single-molecule biophysical chemist
 ry\, coherent Raman scattering microscopy\, and single-cell genomics\, he 
 made major contributions to the emergence of these fields. In particular\,
  his inventions in single-cell genomics have been used in in vitro fertili
 zation to benefit hundreds of couples in China by avoiding the transmissio
 n of monogenic diseases to their newborns.\n
DTSTART:20190219T180000Z
DTEND:20190219T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:The 2018/2019 Belleau Lecture: Sunny Xie - Single Cell Genomics: Wh
 en Stochasticity Meets Precision
URL:/chemistry/channels/event/20182019-belleau-lecture
 -sunny-xie-single-cell-genomics-when-stochasticity-meets-precision-292495
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