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UID:20251108T153715EST-1116sv15Vn@132.216.98.100
DTSTAMP:20251108T203715Z
DESCRIPTION:Abstract:\n\nWhile palladium-based synthetic methods including 
 C(sp2)-N cross-coupling (aka Buchwald-Hartwig amination) are useful\, the 
 cost and rarity of palladium provides motivation for the development of al
 ternative protocols that make use of inexpensive and abundant base-metals.
  Nickel-catalyzed C(sp2)-N cross-coupling holds significant promise in thi
 s regard\; however\, little is known regarding the types of supporting anc
 illary ligands that can enable nickel to do the work of palladium. In resp
 onse\, our research group has recently developed the PAd-DalPhos ligand\, 
 and have shown that the derived complex (PAd-DalPhos)Ni(o-tolyl)Cl (see in
 set) is a superlative pre-catalyst for C(sp2)-N cross-couplings encompassi
 ng a broad substrate scope with respect to both the amine (e.g.\, ammonia\
 , alkylamines\, and amides) and aryl electrophile coupling partners\, as w
 ell as challenging C(sp2)-O cross-couplings.[1] The development of this ca
 talytic chemistry\, along with details of our on-going experimental and co
 mputational mechanistic investigations\, will be the focus of this present
 ation.\n\n[1] Lead publications: Stradiotto and co-workers: (a) Nature Com
 m. 2016\, 7\, 11073. (b) J. Am. Chem. Soc. 2018\, 140\, 5023.\n\nBio:\n\nP
 rof. Mark Stradiotto received his BSc (Hons.) in Applied Chemistry (1995) 
 and PhD in Organometallic Chemistry (1999) from McMaster University\, the 
 latter under the supervision of Profs. Michael A. Brook and Michael J. McG
 linchey. After conducting research as an NSERC Postdoctoral Fellow at the 
 University of California at Berkeley with Prof. T. Don Tilley (1999-2001)\
 , Mark moved to the Department of Chemistry at Dalhousie University where 
 he now holds the rank of Professor with tenure. Mark has been named a Synl
 ett/Synthesis Promising Young Professor Journal Awardee\, and was awarded 
 the Canadian Society for Chemistry 2012 Strem Chemicals Award for Pure or 
 Applied Inorganic Chemistry. In July 2013\, Mark was named the Dalhousie U
 niversity Alexander McLeod Professor of Chemistry\, and in 2017 he was nam
 ed a Fellow of the Royal Society of Chemistry (UK). In 2018 Mark was the r
 ecipient of the Dalhousie University Faculty of Science Award for Teaching
 .\n
DTSTART:20181120T180000Z
DTEND:20181120T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Mark Stradiotto - Move Over Palladium:  D
 eveloping PAd-DalPhos/Nickel-Catalysed C-N Cross-Couplings 
URL:/chemistry/channels/event/chemical-society-seminar
 -mark-stradiotto-move-over-palladium-developing-pad-dalphosnickel-catalyse
 d-290121
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