Below is a list of the core Biomanufacturing courses for students in the Master's non-thesis program. Please see Policies & Forms for more information about course requirements.
* Each course outline linked to on this page may be from a previous term and may not accurately represent current or future versions of the course.
BIEN 601. cGMP and Regulation in
Biomanufacturing.
Credits: 3
Offered by: Bioengineering (Graduate Studies)
This course is not offered this catalogue year.
Description
Introduction to pillars of current good manufacturing practices (cGMP) in biologics, terminologies, and background; importance of cGMP for biologics manufacturing; principles of design and operation of cGMP facilities; knowledge gap between industrial processes and lab practices on GMP.
- Prerequisites: BIEN 590
- 1. Lectures from experts in the biologics manufacturing industry and translational research units in and around Canada.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 580. Synthetic Biology.
Credits: 3
Offered by: Bioengineering (Faculty of Engineering)
This course is not offered this catalogue year.
Description
Engineering principles in biology, BioBricks and standardization of biological components, parts registries, advanced molecular biology tools for DNA assembly,
genome editing, high-throughput genetic manipulation methods, construction of biological pathways, strategies for transcriptional control, examples of engineered
systems.
- Restriction: Permission of instructor
- 1. (3-2-4)
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 585. Metabolic Engineering.
Credits: 3
Offered by: Bioengineering (Faculty of Engineering)
This course is not offered this catalogue year.
Description
Metabolic engineering role in transition from fossil resources to a bio-based society. Design-build-test-learn cycle of metabolic engineering. Design, genetic engineering and optimization of microbial biocatalysts. Metabolic network analysis, constraint-based modelling of metabolism, microbial production of valuable chemicals. General biochemical engineering practices. Recombinant DNA technology, enzyme function, kinetics and regulation. Cell chemistry, structure and function. Growth models, fermentation, strain development. Case studies.
- 3-2-4
- Prerequisite: Permission of the instructor.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 590. Cell Culture Engineering.
Credits: 3
Offered by: Bioengineering (Faculty of Engineering)
This course is not offered this catalogue year.
Description
Basic principles of cell culture engineering, cell line development and cell culture products途 genomics, proteomics and post-translational modifications途 elements of cell physiology for medium design and bioprocessing途 bioreactor design, scale-up
for animal cell culture and single use equipment途 challenges in downstream processing of cell-culture derived products途 process intensification: fed-batch, feeding strategies and continuous manufacturing途 scale-down and process modeling途 Process Analytical technologies and Quality by Design (QbD) concept.
- (3-0-6)
- Prerequisite: Permission of instructor.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 602. Biomanufacturing for RNA Biologics
.
Credits: 3
Offered by: Bioengineering (Graduate Studies)
This course is not offered this catalogue year.
Description
Fundamental and quantitative overview of RNA biologics. Introduction to RNA biologics associated biomanufacturing unit operations in upstream (design tools and large-scale production systems of DNA templates for in vitro RNA transcription; small-scale and large-scale RNA bioprocessing systems), and downstream approaches for RNA purification (like Tangential flow filtration and RNA-specific chromatography systems) for emerging mRNA therapeutics.
Introduction to established and emerging applications of RNA biologics for gene and cell therapy.
- Prerequisites: BIEN 590 or permission of the instructor
- Corequisites: BIEN 670
- The course includes guest lectures from academic and industry experts in the field of RNA as therapeutics for synthesis, purification, formulation and scale-up of RNA biologics.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 670. Downstream Processing
.
Credits: 3
Offered by: Bioengineering (Graduate Studies)
This course is not offered this catalogue year.
Description
Introduction to downstream processing (DSP) 鈥� principles, characteristics, purpose. Bioprocesses, biomolecules, drug substances, drug products, monoclonal antibodies and Fc fusion proteins, viral vectors, and vaccines. Unit operations - standard practices. Steps and techniques in downstream processing. Harvest and Filtration, Primary capture, Buffer exchange and up-concentration, Purification, Bioconjugation, Formulation. Optimization of downstream processing. Process Analytical Technology (PAT) to support Quality by Design (QbD) in DSP. Regulatory guidelines. Innovative Techniques for Downstream Bioprocessing.
- Prerequisites: BIEN 590 or permission of the instructor
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 675. Process Analytical Technologies and Data Sciences
.
Credits: 3
Offered by: Bioengineering (Graduate Studies)
This course is not offered this catalogue year.
Description
Introduction to Process Analytical Technologies (PAT) and Quality by Design (QbD) in the area of manufacturing biologics. Critical Process Parameters (CPP) and Design
Space. Analytical Technologies for Biologics and Biologic Medicines and determination of Critical Quality Attributes of products. Case studies. At-line, On-line and Off-line
monitoring tools, data acquisition and advanced process control strategies as applied to current industrial biomanufacturing. PAT data processing and modeling to design advanced biomanufacturing processes.
- Prerequisites: BIEN 590 or permission of the instructor.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 680. Bioprocessing of Vaccines.
Credits: 4
Offered by: Bioengineering (Graduate Studies)
This course is not offered this catalogue year.
Description
Building on recent developments and expansion in the mammalian cell culture for production of complex biologics such as viral vaccines and viral vectors, the following topics will be covered: Principles of immunology and industrial virology; Cell physiology for vaccine production; Cell lines for vaccine production; Upstream process development and process intensification strategies; Purification and
downstream processing of viral vaccines; Analytical and potency assays; Formulations and delivery of vaccines; Basics of clinical trials and regulatory principles; Immunization policies. Case studies on bioprocessing/manufacturing licensed vaccines.
- Prerequisite: Permission of Instructor.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BIEN 685. Gene and Cell Therapy Viral Vectors Biomanufacturing.
Credits: 3
Offered by: Bioengineering (Graduate Studies)
This course is not offered this catalogue year.
Description
Basic knowledge in the design and biomanufacturing of viral vectors for gene and cell therapy interventions. Practical examples and case studies highlighting challenges and solutions associated with use of viral vectors such as Adeno-Associated Vectors (AAV), lentivirus vectors and Adenovirus vectors for gene delivery. Fundamental principles of gene and cell therapies through in-vivo and ex-vivo interventions. Design of AAV, Lentivirus and Adenovirus vectors: example of targeted diseases, including CAR-T cell therapy. Technologies and modes of vector manufacturing for clinical use.
- Prerequisites: BIEN 590 or permission of the instructor
- Restrictions: Not open to students who have taken or are taking BIEN 680
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BMDE 505. Cell and Tissue Engineering.
Credits: 3
Offered by: Biomedical Engineering (Faculty of Engineering)
This course is not offered this catalogue year.
Description
Application of the principles of engineering, physical, and biological sciences to modify and create cells and tissues for therapeutic applications will be discussed, as well as the industrial perspective and related ethical issues.
- (3-0-6)
- 1.5 hours lecture/1.5 hours seminar per week
- Restriction: graduate and final year undergraduate students from physical, biological, and medical science, and engineering.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
BMDE 507. Formulation and Delivery of Biotherapeutics.
Credits: 3
Offered by: Biomedical Engineering (Faculty of Engineering)
This course is not offered this catalogue year.
Description
Introduction to technologies for formulation and delivery of biotherapeutics. Emphasis is placed on the fundamental principles of formulation, delivery systems, manufacturing,
analytical techniques, and biomedical applications. Translational aspects are considered for formulated biotherapeutic products.
- Prerequisites CHEE 380 (or equivalent), CHEM 212 (or equivalent), and BIOL 201 (or equivalent), or permission of the instructor.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
CHEE 512. Stem Cell Bioprocess Engineering.
Credits: 3
Offered by: Chemical Engineering (Faculty of Engineering)
This course is not offered this catalogue year.
Description
Introduction to stem cell biology. Cell growth models applicable to stem cells and their progeny. Upstream processing (cell culture systems, bioreactors), downstream processing (cell separation, purification) and quality management (current good manufacturing practice, regulations) applied to therapeutic cells.
- (3-0-6)
- Prerequisite(s): MATH 262 and CHEE 370 or BIOL 200, or Permission of Instructor.
- Restriction: Open to undergraduate and graduate students registered in Chemical Engineering, as well as graduate students registered in the 51吃瓜网Graduate Certificate in Regenerative Medicine program or in the M.Eng. in Biological and Biomedical Engineering program.
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.
CHEE 651. Advanced Biochemical Engineering.
Credits: 4
Offered by: Chemical Engineering (Graduate Studies)
This course is not offered this catalogue year.
Description
The use of chemical engineering and biological principles in the study, design, use and creation of biologically-based processes and products. Topics: biochemical thermodynamics, protein engineering, manipulation of gene expression, transport phenomena and bioreactor design.
- Restriction: Restricted to graduate students
Most students use Visual Schedule Builder (VSB) to organize their schedules. VSB helps you plan class schedules, travel time, and more.