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Constitutive relations of cell motion and morphodynamics of cells on 1dimensional lanes

Martin Falcke, Humboldt University
Tuesday November 18, 12-1pm
Zoom Link:听
In Person: 550 Sherbrooke, Room 189

Abstract:听Living cells are very complex systems. Consequently, biophysical theory of cell behavior starts from models instead of first principles. The larger the variety of observations captured by a model the more we have reason to assume that it reflects cellular processes. Simple models are possible in some cases. We present an example from cell motility.

The ability to move is a basic property of many cell types. The motion of cells is essential for embryonic development, wound healing, immune responses, and tumor metastasis. Cells moving on flat substrates exhibit a large variety of migration behavior and patterns. General constitutive relations that relate adhesion density and the time between direction changes (persistence time) to cell speed have been suggested to exist despite this variety. Concurrently, moving cells of many types exhibit coexisting steady and oscillatory morphodynamics. Since cells exhibit these morphodynamics while moving according to the constitutive relations all of these observations should be explained by a single biophysical model.

We investigated cell motion on 1dimensional Fibronectin lanes. We will also present theory offering an explanation for our observations. According to it, moving cells are non-linear mechanical systems the parameters of which are controlled by cell signalling